Biest: Most commonly an 80:20 ratio of estriol and estradiol. This combination allows for all of the protection of estriol while providing the cardiovascular and osteoporosis benefits and vasomotor symptom relief of estradiol.
Cholesterol: Cholesterol molecules are transformed into pregnenolone precursors. Cholesterol is the starting point for the hormone process.
Cortisone: The major natural glucocorticoid made by the adrenal cortex. High levels are often associated with puffiness, high blood pressure, diabetes, and heart disease. Hydrocortisone is produced by the adrenal glands. Hydrocortisone helps boost the immune system to assist in recovery from infections, illness, or stress. Hydrocortisone may be beneficial in treating autoimmune disorders such as Crohn’s, multiple sclerosis, lupus, fibromyalgia, and rheumatoid arthritis.
DHEA: A steroid hormone produced by the adrenals, DHEA has been shown to protect against cancer and heart disease and to lower blood cholesterol. DHEA has also been shown to improve memory, strengthen the immune system, prevent bone loss, reduce body fat and enhance libido.
Estrone (E1): Most commonly found in increased amounts in postmenopausal women, the body derives estrone from the hormones that are stored in body fat. It is considered the most cancer causing of the three estrogens.
• Primary hormone produced after menopause
• More potent than E3
• 10-20% of circulating hormones
• Implicated in hormone mediated cancers
Estradiol (E2): Produced by the ovaries, estradiol is the principal estrogen found in a woman’s body during the reproductive years. Estradiol is very effective for the symptomatic relief of hot flashes, genitourinary symptoms, osteoporosis, psychological well-being and reduction of coronary artery disease. When estradiol is replaced using a sublingual tablet, pellet implant or percutaneous gel, it is not subject to first-pass metabolism by the liver, and therefore does not produce high levels of estrone. Using these routes of administration, a woman can mimic the physiologic release of estradiol from the ovaries.
• Primary hormone produced before menopause
• More potent than E1
• Found in patches
• 10-20% of circulating hormones
Estriol (E3): Although considered the weakest of the three estrogens, estriol has potential protective properties against the production of cancerous cells. No American drugs contain estriol and, because it cannot be patented, it does not hold much interest for the pharmaceutical industry. Its availability through compounding has caused its use to grow rapidly throughout the country.
• Weakest estrogen
• The most protective estrogen
• Not patentable-compound only
• Converted from the 2 above hormones
• 60-80% of circulating hormones
• Thought to be anti-carcinogenic; most protective estrogen ever tested against breast cancer
Melatonin: Probably best known for regulating sleep, melatonin is also an excellent anti-oxidant and, most importantly, a regulator of zinc.
Oxytocin: This is a newly researched neuro-hormone that is thought to be deficient or inhibited in many cases and is critical in the female orgasm process. This is the neuro-hormone that is often inhibited by SSRI’s.
Pregnenolone: Often referred to as the “parent hormone,” pregnenolone is synthesized from cholesterol. It is a superhormone that is the key to keeping the brain functioning at peak capacity. Believed to be the most potent memory enhancer, it has also been shown to be beneficial in improving concentration, fighting mental fatigue and relieving severe joint pain and fatigue in arthritis.
Progesterone: The ovaries and the adrenal glands in women and, in smaller amounts, in the testes and the adrenal glands in men, produce progesterone. Levels of progesterone are especially high after ovulation and remain high through mid-cycle.
If pregnancy does not occur, it signals the uterus to shed this lining. Progesterone plays an important role in brain function and is often called the ”feel-good hormone” because of its mood-enhancing and anti-depressant effects. Progesterone is especially beneficial because it keeps the other hormones in balance.
Testosterone: Testosterone works differently in the bodies of men and women, but plays an important role in the overall health and well-being of both sexes. Often called the “hormone of desire” because of its powerful effect on libido, testosterone is also important in building strong muscles, bones, ligaments, as well as increasing energy and easing depression.
Thyroid: Thyroid stimulates hormones. Increased scores on a TSH test usually are viewed as an indication that something is wrong. In reality, TSH is not a reliable test. Thyroid refers to a group of hormones produced in the body. The two main thyroid hormones are thyroxine or T4, and triiodothyronine or T3.
• T4: is produced by the thyroid gland. It is the inactive thyroid hormone in the body.
• T3: is produced in the brain and liver via the conversion of T4: It is the active form of thyroid hormone in the body.
• Thyroid hormones are involved in regulating the body’s metabolism, increasing energy, and regulating the menstrual cycle.
Triest: Most commonly an 80:10:10 ratio of estriol, estradiol, and estrone. Estrone replacement is not normally recommended.
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